Iran has fired multiple ballistic missiles at American military positions in the Middle East, the US military confirmed Tuesday, breaking a three-day pause in hostilities between the two nations.

The Iranian assault took place at 21:45 GMT on Tuesday, according to US Central Command, which stated that all missiles were successfully intercepted. The US military did not disclose specific target locations. Iran has not yet issued a public response to the allegations.

The strike disrupted diplomatic efforts that had been underway during a break in fighting between Washington and Tehran. US President Donald Trump had spoken optimistically about negotiations on Monday, describing talks with Iran as "very friendly" and expressing cautious optimism that progress could be made. However, Trump had also warned that the US remained prepared to resume military operations if necessary.

The attack coincided with Israeli Prime Minister Benjamin Netanyahu's visit to Washington, where he met with Trump at the White House. The two leaders' meeting occurred as Saudi Arabia reported its own incident on Tuesday—the interception and destruction of several drones targeting petroleum facilities in its eastern region. According to Saudi Defence Ministry spokesman Major General Turki Al-Maliki, the drones originated from Iraqi territory and were attributed to Iran-affiliated militia groups.

Control of the Strait of Hormuz remains a central point of contention in ongoing negotiations between the US and Iran. Pentagon data indicates that at least 624 US military service members have been wounded since February, when Trump authorized strikes against Iran. Of these, 417 personnel were injured during Operation Epic Fury, the joint US-Israeli military operation.